Dexpanthenol (B5)

Overview

Dexpanthenol is a derivative of pantothenic acid, also known as Vitamin B5. It’s found in most living cells and, as a result, a wide range of foods. Bacteria living in the gut are also able to synthesize pantothenic acid, but not in large enough quantities to meet dietary needs. Dexpanthenol acts as a precursor of coenzyme A, which plays a major role in the synthesis and oxidation of fatty acids. Coenzyme A is necessary for acetylation reactions and is key to the synthesis of acetylcholine. Acetylcholine is a neurohumoral transmitter active in the parasympathetic nervous system that maintains the normal functions of the intestine. A decrease in acetylcholine levels can lead to decreased peristalsis or even adynamic ileus in extreme cases, impairing the body’s gastrointestinal processes. When prescribed appropriately, dexpanthenol provides the body with the building blocks it needs to produce coenzyme A and adequate amounts of acetylcholine, allowing us to keep the intestines functioning normally. The exact pharmacological mode of action of dexpanthenol is still unknown.

What Is Dexpanthenol Prescribed For?

Dexpanthenol is indicated for intramuscular or intravenous use for those following abdominal surgery, in order to minimize the possibility of paralytic ileus.

Other Uses

Dexpanthenol is a water-soluble vitamin from the B group of vitamins. It may improve energy production by helping to break down fats and carbohydrates and is important for maintaining healthy skin, hair, eyes, and liver.

Dosage, Concentration, Route of Administration

Dosage: Seek advice from a licensed physician, medical director, or other healthcare provider

Concentration: 250mg/ml

Route of Administration: IV/IM

Precautions/Side Effects

There are no known contraindications for dexpanthenol. Precaution should be taken by individuals who are pregnant or breastfeeding, as it is unknown whether this drug may cause fetal or infant harm. Please consult with your doctor prior to use. There are multiple medications that can interact with dexpanthenol. Make sure to bring a current list of medications and supplements when talking to your healthcare provider so they can review and avoid any possible interactions. 

Even though rare, some patients may have allergic reactions to dexpanthenol. Potential signs of an allergic reaction may include:

• – Rash and/or hives
• – Itching, red, swollen, blistered or peeling skin (with or without a fever)
• – Wheezing and tightness in the chest or throat
• – Trouble breathing, swallowing and talking
• – Swelling of the mouth, face, lips, tongue or throat

Stop using Dexpanthenol and call your doctor right away if  any of the following bother you or do not disappear:

• – Upset stomach
• – Vomiting
• – Diarrhea
• – Trouble breathing

Storage

Store at controlled room temperature. Protect from light.